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Deep Brain Stimulation Therapy for Movement Disorders

Andres Lozano: May 7, 2009; Running Time: 0:47:03

About the Lecture

About the Lecture

New tools are enabling neuroscientists to break therapeutic ground against daunting disorders like Parkinson’s Disease (PD). Andres Lozano is one “of a small group of heroes,” in Ann Graybiel’s estimate, whose work is yielding astonishing advances on a variety of fronts.

Treatments for PD, a progressive, degenerative brain disorder, have until recently dealt primarily with the loss of dopamine-releasing neurons, leading to the classic movement disorders associated with PD: tremor, rigidity, akinesia. But Lozano says that by the time these physical problems are diagnosed, “the reality is that the disease started 10-15 years earlier,” and has involved other brain areas. Lozano determined to focus on three such non-motor symptoms of the disease -- gait and posture, depression (in PD and other patients), and cognitive disorders -- and if possible, “reach these circuits, intervene and help patients.”

PD patients have serious problems controlling balance and posture, and animal studies helped pinpoint an area in the brainstem responsible for these functions. Lozano got permission to plant electrodes in humans in this area, and mapped out the sensitivities of neurons to voluntary movements such as flexing an ankle or walking. In six PD patients, Lozano sent a mild electric current into these neurons. He shows videos demonstrating the remarkable improvement in control (a patient pushed no longer falls) with deep brain stimulation (DBS). A serendipitous offshoot of this therapy is that it improves REM sleep, in which PD patients are deficient.

Lozano has been working as well on mapping and targeting areas of the brain involved in depression, which he has found to be hyperactive. He labeled neurons that responded exclusively to sad and disturbing images, and using DBS, he was able to “turn down the hyperactivity,” successfully reversing severe depression in 60% of his 36 subjects.

His final accomplishment emerged by accident: While attempting to treat a patient’s morbid obesity through DBS, Lozano was startled to find when stimulating the man’s thalamus the patient experienced a vivid sense of déjà vu. (He recalled being in a field 30 years earlier with a girlfriend.) The stronger the current, the more details emerged. When the stimulus ended, the memory ceased. Lozano hopes, via DBS, to help patients with memory disorders. Another intriguing discovery: stimulation in the hippocampus, deeply involved in memory, seems to lead to a burst of new neuron development. These DBS studies suggest, says Lozano, that brain circuits for mood, motor control and cognition can be modulated, and we now “need to determine whether they are safe and beneficial to patients.”

Lecture Details

Location: 46-3002

“In some cases we used pure chance, and fluke and serendipity. Who would have thought you’d treat someone with obesity and you’d end up treating memory? So you have to be always on the lookout for these collateral effects you were not expecting. ”

Andres Lozano

About the Speaker

Andres Lozano

Senior Scientist, Division of Brain Imaging & Behaviour Systems - Neuroscience, Toronto Western Research Institute (TWRI)
Professor, Department of Surgery, and inaugural Chair Holder, the Ron Tasker Chair in Stereotactic and Functional Neurosurgery, University Health Network

Andres Lozano works on novel surgical approaches to treat Parkinson's disease, depression and Alzheimer's disease. His labs use brain imaging, electrophysiology and surgical techniques. The work in humans is complemented by laboratory work involving cell death in Parkinson's disease, effects of stimulation on hippocampal neurogenesis and animal models of deep brain stimulation.

A graduate of the University of Ottawa, Faculty of Medicine in 1983, Lozano underwent Neurosurgical Training at McGill University. He became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1990. During his residency in Montreal, Lozano earned his Ph.D. in Experimental Medicine in 1989. He joined the Neurosurgical Staff at the Toronto Western Hospital in 1991.

Andres Lozano

Lozano's University of Toronto website

About the Host

About the Host

McGovern Institute for Brain Research at MIT

The McGovern Institute for Brain Research at MIT is led by a team of world-renowned, neuroscientists committed to meeting two great challenges of modern science: understanding how the brain works and discovering new ways to prevent or treat brain disorders. The McGovern Institute was established in 2000 by Patrick J. McGovern and Lore Harp McGovern, who are committed to improving human welfare, communication and understanding through their support for neuroscience research.